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Dell Inspiron 3. 84. About Microsoft. Microsoft Corporation develops, manufactures, licenses and supports a variety of products and services related to computing. Publisher URL: www. ![]() The Marijuana plant is the most versatile most beneficial herb. It is good for a number of diseases like cancer, glaucoma, chronic pain, stress disorder, aids. Nelumbo nucifera is a perennial, rhizomatous, aquatic herb with the horizontal creeping rhizomes and roots buried in the mud (Plate 1). The rhizome has nodes. Linoelaidic acid is a doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the. Do Herbal Medicines Have Potential for Managing Snake Bite Envenomation? Abstract. Snake envenomation is a global public health problem, with highest incidence in Southeast Asia. Inadequate health services, difficult transportation and consequent delay in antisnake venom administration are the main reasons for high mortality. Adverse drug reactions and inadequate storage conditions limit the use of antisnake venom. The medicinal plants, available locally and used widely by traditional healers, therefore need attention. The gum of the Mimosa Ailot'ica. Amuletum, Alexipharmic. ALEXIPHAR'MIC, Alexiphar'miens, Anti. The Brachmanic name for an Indian aquatic herb. Biodiversity contributes significantly towards human livelihood and development and thus plays a predominant role in the well being of the global population. If you feel you may be in need of some healing, but don't know which products are best for you, read through the information about the products, and if you need to. A wide array of plants and their active principles have been evaluated for pharmacological properties. However, numerous unexplored plants claimed to be antidotes in folklore medicine need to be studied. The present article reviews the current status of various medicinal plants for the management of snake bite. Keywords: Antisnake venom, medicinal plants, pharmacological activity, snake bite. INTRODUCTIONSnake envenomation is an important global health issue. It constitutes an occupational hazard mainly in the field of agriculture. Highest incidence and mortality due to snake bites is reported from South and Southeast Asian countries having extensive agricultural practices and diversity in snake species.[1] Poor health services, difficult transportation, delay in the antisnake venom administration especially in rural areas are the important factors responsible for high mortality. It is estimated that in India alone, there are more than 2,0. The estimates are arbitrary as majority of deaths are unreported. In rural areas, where most of the bites take place, the victims are mostly taken to traditional healers, who neither report them to the authorities nor document the cases, hence paucity of reliable epidemiological data. There are more than 3. In India out of 2. Bites are primarily due to the venomous species of the families Elapidae and Viperidae. The common poisonous snakes in India mainly include Indian spectacled cobra (Naja naja), common krait (Bungarus caeruleus), Russell's viper (Daboia russelii) and saw- scaled viper (Echis carinatus) [Table 1]. Hump- nosed pit vipers (Hypnale hypnale and H. South India.[3]Common poisonous snakes in India. The snake venom is a complex mixture of enzymes including the procoagulants, non- enzyme proteins, peptides, carbohydrates, amines, lipids and metal ions. The venom exerts neurotoxic, cytotoxic and hemotoxic effects. The administration of antisnake venom (ASV), the only specific treatment for snake bite, however, is associated with many drawbacks. Antisnake venom and its limitations. Antivenom for ophidian bites is a suspension of antibodies, prepared mainly from horses. Animals are hyper- immunized against the venom of a given species (monovalent) or venoms from several different species at the same time (polyvalent). Infusion of ASV may lead to adverse reactions ranging from early reactions (pruritus, urticaria) to potentially fatal anaphylaxis[4] [Table 2]. The reported incidence of these reactions varies from 5 to 8. There are also pyrogen reactions due to endotoxin contamination. Serum sickness may also develop in certain cases. Adverse drug reactions profile of antisnake venom. Availability and issues in stockpiling. The production and supply of antivenom is associated with logistical, marketing, storage and economic difficulties. The development is a costly, time- consuming process requiring ideal storage conditions. The liquid form of ASV has a half life of 2 years. Storage at 0–4°C is necessary, otherwise rapid deterioration sets in rendering it unfit for use. However, the lyophilized form retains potency up to 5 years when stored in any cool, dark place. In India, polyvalent antisnake venom is prepared from horses, which are hyper- immunized against the venom of the four common poisonous snakes (Cobra, Krait, Russell's Viper and Saw- scaled Viper). Issue of specificity. Absolute specificity is an issue in management with ASV. The geographic and taxonomic diversity in species leads to a significant variation in composition and antigenic reactivity of venom.[8,9] So the use of a particular ASV may get restricted to a geographical area of relevant specificity. Thus, monovalent ASV would be the solution. But in view of the cost and diverse specificity, polyvalent ASV would provide answers to an extent, considering the medically important species. However, because of paucity of reliable literature on distribution and diversity of venomous species, ASV is not available for all species. This is one of the main obstacles of immunotherapy. Herbs as an alternative to antisnake venom. The plant kingdom provides an alternative to ASV. Medicinal plants have been used as folk medicine for treatment of snake bites. Reliance on medicinal plants is primarily due to their safety, effectiveness, cultural preferences, inexpensive nature and dependence on neighboring forests. Globally, traditional healers are practicing herbal medicine to cure snake envenomations; however, the practice is not really recognized by modern medicine. The number of studies evaluating the pharmacologically active principles against snake bites are few.[1. Though novel phytotherapeutic agents have been isolated from plants due to vital leads from ethnic groups, yet validation is still an issue. Emphasis should be on proper design of both in vivo and in vitro studies, so that they relate exactly to the clinical situations.[1. This review is an attempt to present a comprehensive account of numerous herbals used world over for the treatment of snake bite. A thorough literature survey highlights the fact that plant kingdom has tremendous resources which can be exploited for unidentified novel compounds with antivenin activity or those supplementing the action of antisnake venom. Herbal plants with antitoxin activity. The indigenous systems of medicine use medicinal plants for the treatment of snake bites. There is a huge repository of plants reported to possess antisnake venom activity.[1. Investigation of therapeutic potential of plants used for snake bites shows the presence of different phytochemicals [Table 3]. Phytochemicals isolated from plants used for snakebites. Screening of plants used in traditional medicine and determination of their active principles and different activities is being undertaken. The active principles isolated have been associated with various pharmacological properties and may provide a substantial contribution to the modern therapeutics of snake bite. Anti- inflammatory activity. Ethanolic extracts of Bixa orellana, Brownea rosa- de- monte, Dracontium croatii, Struthanthus orbicularis, Gonzalagunia panamensis, and Trichomanes elegans are reported to inhibit edema due to Bothrops asper venom.[1. Decrease of edema formation with aqueous extracts of Casearia sylvestris Sw. Bothropic venoms. Ellagic acid has inhibited edematogenic activity due to total venom and phospholipase A2 (PLA2) from Bothrops jararacussu.[1. Methanolic extract of seeds of Vitis vinifera. L. has shown promise for the treatment of local effects of viperine bites. The extract neutralized edema- inducing property of venom.[1. Cordia verbenacea extract significantly reduced paw edema, induced by Bothrops jararacussu snake venom.[1. Different doses of Tamarindus indica seed extract upon preincubation with venom before assays significantly neutralized edema.[1. Anacardium occidentale bark extract has also been shown to neutralize edema induced by viper venom.[2. Lupeol acetate from roots of Hemidesmus indicus. R. Br. is documented to significantly neutralize edema induced by Russell's Viper, in experimental animals, besides the cardiotoxicity, neurotoxicity and respiratory changes induced by Naja kaouthia venom.[2. Antiophidian properties are reported to be associated with triterpenoid saponins. Glycyrrhizin, isolated from the roots of Glycyrrhiza glabra, has been found to be anti- inflammatory.[2. Inhibition of edema due to Naja naja venom is reported with turmerin isolated from Curcuma longa.[2. Bidens pilosa is documented to have anti- inflammatory potential.[2. Strychnos nux- vomica used by tribals for snake bites is reported to be anti- inflammatory.[2. Extracts of Andrographis paniculata and Aristolochia indica have shown significant decrease in edema.[2. Partial inhibition of edema has been reported with the aqueous extracts of Pentaclethra macroloba.[2. Anti- hemorrhagic and anticoagulant activity. 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